Closed-loop functional optogenetic stimulation
نویسندگان
چکیده
منابع مشابه
Closed-Loop and Activity-Guided Optogenetic Control
Advances in optical manipulation and observation of neural activity have set the stage for widespread implementation of closed-loop and activity-guided optical control of neural circuit dynamics. Closing the loop optogenetically (i.e., basing optogenetic stimulation on simultaneously observed dynamics in a principled way) is a powerful strategy for causal investigation of neural circuitry. In p...
متن کاملControlling the oscillation phase through precisely timed closed-loop optogenetic stimulation: a computational study
Dynamic oscillatory coherence is believed to play a central role in flexible communication between brain circuits. To test this communication-through-coherence hypothesis, experimental protocols that allow a reliable control of phase-relations between neuronal populations are needed. In this modeling study, we explore the potential of closed-loop optogenetic stimulation for the control of funct...
متن کاملDesign strategies for dynamic closed-loop optogenetic neurocontrol in vivo.
OBJECTIVE Controlling neural activity enables the possibility of manipulating sensory perception, cognitive processes, and body movement, in addition to providing a powerful framework for functionally disentangling the neural circuits that underlie these complex phenomena. Over the last decade, optogenetic stimulation has become an increasingly important and powerful tool for understanding neur...
متن کاملPrototype Closed-Loop Deep Brain Stimulation
Implantable neurostimulators have rapidly become established methods of treating a variety of neurological disorders. The development of implantable neural interfaces enable the testing of Norbert Wiener’s hypotheses regarding neural disorders and their relationship to ideas of cybernetics. However, currently deployed medical devices of this kind are open-loop. For example, DBS for treatment of...
متن کاملClosed- and Open-loop Deep Brain Stimulation: Methods, Challenges, Current and Future Aspects
Deep brain stimulation (DBS) is known as the most effective technique in the treatment of neurodegenerative diseases, especially Parkinson disease (PD) and epilepsy. Relative healing and effective control of disease symptoms are the most significant reasons for the tangible tendency in use and development of this technology. Nevertheless, more cellular and molecular investigations are required ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Communications
سال: 2018
ISSN: 2041-1723
DOI: 10.1038/s41467-018-07721-w